As a result of the military reforms of Philip in the IV century BC. The Macedonian kingdom has become a powerful strong state. Subsequently, these legacies, Alexander the Great, in order to achieve world hegemony, received the opportunity of a devastating victory over the strong Persian Empire. In all these battles against the hegemony of Alexander the Great, the Saks participated as allies of the Persians. However, despite the high fighting spirit of the Saks, due to the weakness of Darius III, the Greco-Macedonian army won. Developing military achievements and success, the army of Alexander the Great invaded the Saka possessions. This article tells on the basis of sources about the struggle for freedom of the Saks in opposition to Alexander the Great. The battle of the Saks led by Spitamen with the troops of Alexander the Great is especially thoroughly analyzed.