The Great Silk Road was a network of caravan routes which connected the East and West in the ancient and medieval times. In this article the impact of the Silk Road on the development of trade and the growth of cities in the Kazakh territory has been given as an example of Saraishyk city located on the Zhaiyk river. To examine one of the oldest cities of Desht-I Kipchak, Saraishyk and its emergence, prosperity, rise and fall would be a great contribution to the research of the old cities of Kazakhstan. Therefore, the author makes some statements relying on the works of scholars and archeologists such as N. Arzuytov, E. Ageeva, A. Margulan and others who conducted archeological excavations on Saraishyk city. The role of the Great Silk Road in the prosperity of Saraishyk city as a cultural, administrative and