Bilateral cooperation between the Republics of Uzbekistan and Kazakhstan are discussed in the article. The Republic of Uzbekistan and the Republic of Kazakhstan are on the threshold of a new relationship, which will be aimed at creating a stable economic situation throughout Central Asia, which will make us an economically powerful region of the world. Also, in the article the economic and human potential of both states are analyzed, common historical roots and long-standing friendship are examined. The authors come to the conclusion that the main task of the Republic of Uzbekistan is to maximize the potential of Kazakh-Uzbek cooperation to achieve strategic benefits for the two countries